Neural mechanisms responsible for vagus nerve stimulation-dependent enhancement of somatosensory recovery.

ABSTRACT: Impairments in somatosensory function are a common and often debilitating consequence of neurological injury, with few effective interventions. Building on success in rehabilitation for motor dysfunction, the delivery of vagus nerve stimulation (VNS) combined with tactile rehabilitation has emerged as a potential approach to enhance recovery of somatosensation. In order to maximize the effectiveness of VNS therapy and promote translation to clinical implementation, we sought to optimize the stimulation paradigm and identify neural mechanisms that underlie VNS-dependent recovery. To do so, we characterized the effect of tactile rehabilitation combined with VNS across a range of stimulation intensities on recovery of somatosensory function in a rat model of chronic sensory loss in the foreli

SUBMITTER: Malley KM 

PROVIDER: S-EPMC11339300 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature