Time-of-day effects of cancer drugs revealed by high-throughput deep phenotyping.

ABSTRACT: The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the circadian rhythm can enhance treatment efficacy and minimize side effects. Yet, uncovering the optimal treatment timings remains challenging, limiting their widespread adoption. In this work, we introduce a high-throughput approach integrating live-imaging and data analysis techniques to deep-phenotype cancer cell models, evaluating their circadian rhythms, growth, and drug responses. We devise a streamlined process for profiling drug sensitivities across different times of the day, identifying optimal treatment windows and responsive cell t

SUBMITTER: Ector C 

PROVIDER: S-EPMC11339390 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature