A physical derivation of high-flux ion transport in biological channel via quantum ion coherence.

ABSTRACT: Biological ion channels usually conduct the high-flux transport of 10⁷ ~ 10⁸ ions·s^-1; however, the underlying mechanism is still lacking. Here, by applying the KcsA potassium channel as a typical example, and performing multitimescale molecular dynamics simulations, we demonstrate that there is coherence of the K⁺ ions confined in biological channels, which determines transport. The coherent oscillation state of confined K⁺ ions with a nanosecond-level lifetime in the channel dominates each transport event, serving as the physical basis for the high flux of ~10⁸ ions∙s^-1. The coherent transfer of confined K⁺ ions only takes several picoseconds and has no perturbation effect on the

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11339410 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature