OTULIN's influence on neuroinflammation and pain modulation in trigeminal neuralgia.

ABSTRACT: Trigeminal neuralgia (TN), marked by chronic pain from neural damage, is closely associated with inflammation. The role of OTULIN, a key regulator in inflammation and autophagy, is not fully understood in TN. The regulatory mechanism of OTULIN, a key protein involved in modulating inflammatory responses and autophagy processes, remains incompletely elucidated, particularly in the context of TN and neuroinflammation. An infraorbital nerve ligation-induced rat model of TN was used. OTULIN's expression was modulated using adenovirus vectors and short hairpin RNA. The impact on pain and inflammatory responses was assessed via quantitative real-time polymerase chain reaction, western blot, immunofluorescence, and transcriptomic analysis. Enhanced OTULIN expression significantly increased head w

SUBMITTER: Wang H 

PROVIDER: S-EPMC11339468 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature