Bidirectional negative relationship between thyrotropin and kidney function during alcohol intoxication in males.

ABSTRACT:

Introduction

Despite a well-established direct toxic effect of alcohol on renal cells, there is a salutary dose-dependent effect of alcohol consumption on common laboratory parameters related to kidney performance. Alcohol also impacts thyroid hormones, while thyroid status modulates kidney function. The modulation of kidney parameters with thyrotropin (TSH) and thyroid status indicates a possible interaction between alcohol, kidney, and thyroid functions. This retrospective study was conducted to test the hypothesis that the positive effect of alcohol use on the estimated glomerular filtration rate (eGFR) is mediated by alcohol's effect on thyroid hormones.

Methods

We reviewed the electronic medical records of 767 hospitalized adult patients free of thyroid disorders who re

SUBMITTER: Unlu H 

PROVIDER: S-EPMC11339534 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature