Predictive biomarkers for metachronous gastric cancer development after endoscopic resection of early gastric cancer.

ABSTRACT:

Objectives

We aimed to identify predictive markers for metachronous gastric cancer (MGC) in early gastric cancer (EGC) patients curatively treated with endoscopic submucosal dissection (ESD).

Materials and methods

From EGC patients who underwent ESD, bulk RNA sequencing was performed on non-cancerous gastric mucosa samples at the time of initial EGC diagnosis. This included 23 patients who developed MGC, and 23 control patients without additional gastric neoplasms for over 3 years (1:1 matched by age, sex, and Helicobacter pylori infection state). Candidate differentially-expressed genes were identified, from which biomarkers were selected using real-time quantitative polymerase chain reaction and cell viability assays using gastric cell lines. An independent validation coho

SUBMITTER: Kim B 

PROVIDER: S-EPMC11339598 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature