Trajectories of Inflammation in Youth and Risk of Mental and Cardiometabolic Disorders in Adulthood.

ABSTRACT:

Importance

Research suggests that low-grade, nonresolving inflammation may predate adult mental and physical illness. However, evidence to date is largely cross-sectional or focuses on single disorder outcomes.

Objectives

To examine trajectories of inflammation as measured by C-reactive protein (CRP) levels in a large sample of children and adolescents, and to explore associations between different identified trajectories and mental and related cardiometabolic health outcomes in early adulthood.

Design, setting, and participants

In a longitudinal cohort study using data from the large UK-based Avon Longitudinal Study of Parents and Children (ALSPAC), latent class growth analysis (LCGA) was used to explore different trajectories of inflammation, with logistic regressio

SUBMITTER: Palmer ER 

PROVIDER: S-EPMC11339695 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature