Peri- and intra-nodular radiomic features based on ¹⁸F-FDG PET/CT to distinguish lung adenocarcinomas from pulmonary granulomas.

ABSTRACT:

Objective

To compare the effectiveness of radiomic features based on ¹⁸F-FDG PET/CT images within (intranodular) and around (perinodular) lung nodules/masses in distinguishing between lung adenocarcinoma and pulmonary granulomas.

Methods

For this retrospective study, ¹⁸F-FDG PET/CT images were collected for 228 patients. Patients diagnosed with lung adenocarcinoma (n = 156) or granulomas (n = 72) were randomly assigned to a training (n = 159) and validation (n = 69) groups. The volume of interest (VOI) of intranodular, perinodular (1-5 voxels, termed Lesion_margin1 to Lesion_margin5) and total area (intra- plus perinodular region, termed Lesion_total1 to Lesion_total5) on PET/CT images were delineated using PETtumor and Marge

SUBMITTER: Tian C 

PROVIDER: S-EPMC11339787 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature