Sustained-Release Microspheres of Cyclodextrin-Resveratrol Complex Using Fenugreek Galactomannan Hydrogels: A Green Approach to Phytonutrient Delivery.

ABSTRACT: Food matrices are becoming increasingly complex with the impregnation of phytonutrients with health-beneficial pharmacological effects. Herein, we report the preparation, characterization, and functional application of soluble and stable microspheres of trans-resveratrol (t-RES) developed through a water-based green process involving cyclodextrin (CD) and fenugreek galactomannan (FG). Spectroscopic and thermodynamic calculations identified γ-CD as the best CD to form a stable cyclodextrin-resveratrol inclusion complex (CD-R, 49-fold enhanced solubility); however, it exhibited a burst release profile. The sustained release of resveratrol was achieved by further encapsulating the inclusion complex within the fenugreek galactomannan hydrogel scaffold by a gel-phase dispersion pr

SUBMITTER: Kannamangalam Vijayan U 

PROVIDER: S-EPMC11339820 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature