Genetic Signatures of Positive Selection in Human Populations Adapted to High Altitude in Papua New Guinea.

ABSTRACT: Papua New Guinea (PNG) hosts distinct environments mainly represented by the ecoregions of the Highlands and Lowlands that display increased altitude and a predominance of pathogens, respectively. Since its initial peopling approximately 50,000 years ago, inhabitants of these ecoregions might have differentially adapted to the environmental pressures exerted by each of them. However, the genetic basis of adaptation in populations from these areas remains understudied. Here, we investigated signals of positive selection in 62 highlanders and 43 lowlanders across 14 locations in the main island of PNG using whole-genome genotype data from the Oceanian Genome Variation Project (OGVP) and searched for signals of positive selection through population differentiation and haplotype-based selectio

SUBMITTER: Gonzalez-Buenfil R 

PROVIDER: S-EPMC11339866 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature