Causal relationship between gut microbiota and gynecological tumor: a two-sample Mendelian randomization study.

ABSTRACT:

Introduction

Previous research has established associations between alterations in gut microbiota composition and various gynecologic tumors. However, establishing a causal relationship between gut microbiota and these tumors remains necessary. This study employs a two-sample Mendelian randomization (MR) approach to investigate causality, aiming to identify pathogenic bacterial communities potentially involved in gynecologic tumor development.

Methods

Data from the MiBioGen consortium's Genome-Wide Association Study (GWAS) on gut microbiota were used as the exposure variable. Four common gynecologic neoplasms, including uterine fibroids (UF), endometrial cancer (EC), ovarian cancer (OC), and cervical cancer (CC), were selected as outcome variables. Single-nucleotide polymorp

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC11339882 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature