Novel thermoplastic microvalves based on an elastomeric cyclic olefin copolymer.

ABSTRACT: Microfluidic systems combine multiple processing steps and components to perform complex assays in an autonomous fashion. To enable the integration of several bio-analytical processing steps into a single system, valving is used as a component that directs fluids and controls introduction of sample and reagents. While elastomer polydimethylsiloxane has been the material of choice for valving, it does not scale well to accommodate disposable integrated systems where inexpensive and fast production is needed. As an alternative to polydimethylsiloxane, we introduce a membrane made of thermoplastic elastomeric cyclic olefin copolymer (eCOC), that displays unique attributes for the fabrication of reliable valving. The eCOC membrane can be extruded or injection molded to allow for high scale pro

SUBMITTER: Childers K 

PROVIDER: S-EPMC11339931 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature