The response to influenza vaccination is associated with DNA methylation-driven regulation of T cell innate antiviral pathways.

ABSTRACT:

Background

The effect of vaccination on the epigenome remains poorly characterized. In previous research, we identified an association between seroprotection against influenza and DNA methylation at sites associated with the RIG-1 signaling pathway, which recognizes viral double-stranded RNA and leads to a type I interferon response. However, these studies did not fully account for confounding factors including age, gender, and BMI, along with changes in cell-type composition.

Results

Here, we studied the influenza vaccine response in a longitudinal cohort vaccinated over two consecutive years (2019-2020 and 2020-2021), using peripheral blood mononuclear cells and a targeted DNA methylation approach. To address the effects of multiple factors on the epigenome, we designed a

SUBMITTER: Fu H 

PROVIDER: S-EPMC11340180 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature