Novel crossover and recombination hotspots massively spread across primate genomes.

ABSTRACT:

Background

The recombination landscape and subsequent natural selection have vast consequences forevolution and speciation. However, most of the crossover and recombination hotspots are yet to be discovered. We previously reported the relevance of C and G trinucleotide two-repeat units (CG-TTUs) in crossovers and recombination.

Methods

On a genome-wide scale, here we mapped all combinations of A and T trinucleotide two-repeat units (AT-TTUs) in human, consisting of AATAAT, ATAATA, ATTATT, TTATTA, TATTAT, and TAATAA. We also compared a number of the colonies formed by the AT-TTUs (distance between consecutive AT-TTUs < 500 bp) in several other primates and mouse.

Results

We found that the majority of the AT-TTUs (> 96%) resided in approximately 1.4 million colonies, sp

SUBMITTER: Ohadi M 

PROVIDER: S-EPMC11340189 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature