Effect of chronic kidney disease on adverse drug reactions to anti-tubercular treatment: a retrospective cohort study.

ABSTRACT:

Introduction

Patients with chronic kidney disease (CKD) are at increased risk of developing tuberculosis (TB). These patients may also be at higher risk of developing antitubercular treatment (ATT)-associated adverse drug reactions (ADRs). Although dose modification has been recommended, data regarding the impact of impaired kidney function on ATT-associated ADRs is sparse. We studied the incidence and profile of ATT-associated ADRs in patients with CKD and compared them with those with normal kidney function.

Methodology

This retrospective study analyzed all patients initiated on ATT from January 2016 to August 2019. Patients were grouped into CKD and normal kidney function based on their eGFR. Data on ATT-associated ADRs were collected from medical records. Predictors of A

SUBMITTER: Datta D 

PROVIDER: S-EPMC11340219 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature