Investigating the self-assembly of 2NapFF and ureido-pyrimidinone multicomponent systems for cell culture.

ABSTRACT: Low molecular weight gels are formed via the self-assembly of small molecules into fibrous structures. In the case of hydrogels, these networks entrap large volumes of water, yielding soft materials. Such gels tend to have weak mechanical properties and a high permeability for cells, making them particularly appealing for regenerative medicine applications. Ureido-pyrimidinone (UPy) supramolecular gelators are self-assembling systems that have demonstrated excellent capabilities as biomaterials. Here, we combine UPy-gelators with another low molecular weight gelator, the functionalized dipeptide 2NapFF. We have successfully characterized these multicomponent systems on a molecular and bulk scale. The addition of 2NapFF to a crosslinked UPy hydrogel significantly increased hydrogel s

SUBMITTER: Wallace CM 

PROVIDER: S-EPMC11340344 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature