Design, synthesis, anticancer and in silico assessment of 8-caffeinyl chalcone hybrid conjugates.

ABSTRACT: In this paper, we report the design, synthesis, and characterization of novel 8-caffeinyl chalcone hybrid conjugates, which were studied for their anticancer properties, toxicity, and in silico behavior. The synthesized compounds consist of 8-caffeinyl and chalcone structures with diverse substituents. The synthesis involved three main stages: bromination of caffeine to produce 8-BC, synthesis of chalcones, and subsequent coupling of these chalcones with 8-BC. The anticancer activity of the resulting compounds was evaluated in vitro against breast cancer MCF-7 and melanoma A-375 cell lines, revealing certain compounds to have significant efficacy compared to the reference drug methotrexate. Toxicity assessments using a healthy cell line indicated that most compounds displayed

SUBMITTER: Soltani Rad MN 

PROVIDER: S-EPMC11340408 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature