CAN008 prolongs overall survival in patients with newly diagnosed GBM characterized by high tumor mutational burden.

ABSTRACT:

Background

A previous phase 1 dose-escalation study in Taiwan indicated CAN008 (asunercept) with standard concurrent chemoradiotherapy (CCRT) improved progression-free survival (PFS) in newly diagnosed glioblastoma (GBM) patients. This study evaluates the efficacy of CAN008 in promoting overall survival (OS) and identifies genetic alterations associated with treatment responses.

Methods

We compared OS of 5-year follow-ups from 9 evaluable CAN008 cohort patients (6 received high-dose and 3 received low-dose) to a historical Taiwanese GBM cohort with 164 newly diagnosed patients. CAN008 treatment response-associated genetic alterations were identified by whole-exome sequencing and comparing variant differences between response groups. Associations among patient survival, tumor

SUBMITTER: Chang IY 

PROVIDER: S-EPMC11340566 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature