Functional distinction in oncogenic Ras variant activity in Caenorhabditis elegans.

ABSTRACT: Ras genes are important oncogenes that are frequently mutated in cancer. Human oncogenic variants exhibit functional distinctions in terms of their representation in different cancer types, impact on cellular targets and sensitivity to pharmacological treatments. However, how these distinct variants influence and respond to the cellular networks in which they are embedded is poorly understood. To identify novel participants in the complex interplay between Ras genotype and cell interaction networks in vivo, we have developed and tested an experimental framework using a simple vulva-development assay in the nematode C. elegans. Using this system, we evaluated a set of Ras oncogenic substitution changes at G12, G13 and Q61. We found that these variants fall into distinct groups based on phen

SUBMITTER: Lyu H 

PROVIDER: S-EPMC11340813 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature