A SIRT1-independent mechanism mediates protection against steroid-induced senescence by resveralogues in equine tenocytes.

ABSTRACT: Tendinopathy is a common age-related disease which causes significant morbidity for both human athletes and performance horses. In the latter, the superficial digital flexor tendon is an excellent model for human tendinopathies because it is a functional homologue of the human Achilles tendon and a primary site of injuries with strong similarities to the human disease. Corticosteroids have been previously used clinically to treat tendinopathic inflammation, but they upregulate the p53-p21 axis with concomitant reductions in cell proliferation and collagen synthesis in human tenocytes. This phenotype is consistent with the induction of cellular senescence in vitro and in vivo and probably represents an important clinical barrier to their effective use. Because of the many differences in sen

SUBMITTER: Heidari N 

PROVIDER: S-EPMC11340939 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature