Association of hyperuricemia with coronary heart disease: Protocol for an updated systematic review and dose-response meta-analysis.

ABSTRACT:

Introduction

Hyperuricemia, characterized by elevated serum uric acid levels, has garnered significant attention in cardiovascular research due to its potential association with coronary heart disease (CHD). While some studies suggest hyperuricemia as a risk factor of CHD, others present conflicting findings. A systematic review and dose-response meta-analysis is warranted to comprehensively summarize the previous studies and determine the association between hyperuricemia and CHD, thereby supporting clinical practice and future studies in this field.

Methods

In this study, we will comprehensively search Medline, EMBase, Cochrane Central, ICTRP, and ClinicalTrials.gov, from inception to December 31, 2024. Prospective or retrospective cohort studies and case-control studies i

SUBMITTER: Chen J 

PROVIDER: S-EPMC11340979 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature