Associations of age at diagnosis of breast cancer with incident myocardial infarction and heart failure: A prospective cohort study.

ABSTRACT:

Background

The associations of age at diagnosis of breast cancer with incident myocardial infarction (MI) and heart failure (HF) remain unexamined. Addressing this problem could promote understanding of the cardiovascular impact of breast cancer.

Methods

Data were obtained from the UK Biobank. Information on the diagnosis of breast cancer, MI, and HF was collected at baseline and follow-ups (median = 12.8 years). The propensity score matching method and Cox proportional hazards models were employed.

Results

A total of 251,277 female participants (mean age: 56.8 ± 8.0 years), of whom 16,241 had breast cancer, were included. Among breast cancer participants, younger age at diagnosis (per 10-year decrease) was significantly associated with elevated risks of MI (hazard ra

SUBMITTER: Liang J 

PROVIDER: S-EPMC11341089 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature