Model-based frequency-and-phase correction of ¹H MRS data with 2D linear-combination modeling.

ABSTRACT:

Purpose

Retrospective frequency-and-phase correction (FPC) methods attempt to remove frequency-and-phase variations between transients to improve the quality of the averaged MR spectrum. However, traditional FPC methods like spectral registration struggle at low SNR. Here, we propose a method that directly integrates FPC into a 2D linear-combination model (2D-LCM) of individual transients ("model-based FPC"). We investigated how model-based FPC performs compared to the traditional approach, i.e., spectral registration followed by 1D-LCM in estimating frequency-and-phase drifts and, consequentially, metabolite level estimates.

Methods

We created synthetic in-vivo-like 64-transient short-TE sLASER datasets with 100 noise realizations at 5 SNR levels and added randomly sampled

SUBMITTER: Simicic D 

PROVIDER: S-EPMC11341254 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature