The combined use of serum Raman spectroscopy and D dimer testing for the early diagnosis of acute aortic dissection.

ABSTRACT:

Objectives

Acute aortic dissection (AAD) is an extremely life-threatening medical emergency, often misdiagnosed in its early stages, resulting in prolonged wait times for rescue. This study aims to identify potential serum biomarkers that can assist in the accurate diagnosis of AAD and effectively differentiate it from other conditions causing severe chest pain.

Methods

A total of 122 patients with AAD and 129 patients with other severe chest pain disorders were included in the study. Serum samples were analyzed by measuring the peak intensities of Raman spectra. For each measurement, the Raman spectrum was accumulated by two accumulations (3 s per acquisition). Logistic regression and nomogram models were developed using these peak intensities as well as D-dimer levels to p

SUBMITTER: Han X 

PROVIDER: S-EPMC11341313 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature