Investigating potential novel therapeutic targets and biomarkers for ankylosing spondylitis using plasma protein screening.

ABSTRACT:

Background

Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting the spine and sacroiliac joints. Recent genetic studies suggest certain plasma proteins may play a causal role in AS development. This study aims to identify and characterize these proteins using Mendelian randomization (MR) and colocalization analyses.

Methods

Plasma protein data were obtained from recent publications in Nature Genetics, integrating data from five previous GWAS datasets, including 738 cis-pQTLs for 734 plasma proteins. GWAS summary data for AS were sourced from IGAS and other European cohorts. MR analyses were conducted using "TwoSampleMR" to assess causal links between plasma protein levels and AS. Colocalization analysis was performed with the coloc R package to iden

SUBMITTER: You W 

PROVIDER: S-EPMC11341372 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature