Dataset Information

Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study.

ABSTRACT:

Background

Previous studies have demonstrated the benefits of ideal cardiovascular health (CVH) in reducing cardiovascular risk. However, its role in subclinical atherosclerosis (SA) progression remains unclear. We aim to examine the association of CVH, estimated by the American Heart Association's new Life's Essential 8 (LE8), with the progression of SA.

Methods

This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for 5.7 years. The LE8 score (range, 0-100) consisted of blood pressure, lipids, glucose, body mass index, smoking status, diet health, physical activity and sleep health was evaluated in 1998 and 2008-2009. Progression of SA was determined by carotid plaque and coronary artery calcification (CAC) in 2008-2009 and 2013-2014. Log-binomial regression model was used to estimate the association of LE8 score with SA progression.

Results

Each 10 points increment in LE8 score was associated with 15.2% (RR: 0.848, 95% CI: 0.797-0.902), 17.7% (RR: 0.823, 95% CI: 0.766-0.884) and 12.0% (RR: 0.880, 95% CI: 0.845-0.916) lower risks of carotid plaque, CAC and overall SA progression, respectively. Compared with participants with non-ideal CVH at both visits, the participants with ideal CVH at both visits had 39.1% (RR: 0.609, 95% CI: 0.494-0.752), 41.0% (RR: 0.590, 95% CI: 0.456-0.764) and 29.7% (RR: 0.703, 95% CI: 0.598-0.825) lower risks of carotid plaque, CAC and overall SA progression, respectively.

Conclusions

Higher LE8 scores were associated with lower risks of SA progression. Besides, long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

SUBMITTER: Zhou SY

PROVIDER: S-EPMC11341528 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature

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Publications

Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study.

Zhou Shi-Yu SY Liu Fang-Chao FC Chen Shu-Feng SF Li Jian-Xin JX Cao Jie J Huang Ke-Yong KY Tang Zheng-Hao ZH Liang Feng-Chao FC Hu Dong-Sheng DS Zhao Lian-Cheng LC Li Ying Y Huang Jian-Feng JF Lu Xiang-Feng XF Lu Bin B Gu Dong-Feng DF

Journal of geriatric cardiology : JGC 20240701 7

<h4>Background</h4>Previous studies have demonstrated the benefits of ideal cardiovascular health (CVH) in reducing cardiovascular risk. However, its role in subclinical atherosclerosis (SA) progression remains unclear. We aim to examine the association of CVH, estimated by the American Heart Association's new Life's Essential 8 (LE8), with the progression of SA.<h4>Methods</h4>This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for 5.7 years. ...[more]

PMID: 39183952

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Dataset Information

Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study.

Background

Methods

Results

Conclusions

Publications

Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study.

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