Effect of Jardiance on glucose uptake into astrocytomas.

ABSTRACT:

Purpose

SGLT2, the sodium glucose cotransporter two, is expressed in human pancreatic, prostate and brain tumors, and in a mouse cancer model SGLT2 inhibitors reduce tumor glucose uptake and growth. In this study we have measured the effect of a specific SGLT2 inhibitor, Jardiance® (Empagliflozin), on glucose uptake into astrocytomas in patients.

Methods

We have used a specific SGLT glucose tracer, α-methyl-4-[¹⁸F]fluoro-4-deoxy-α-D-glucopyranoside (Me4FDG), and Positron Emission Tomography (PET) to measure glucose uptake. Four of five patients enrolled had WHO grade IV glioblastomas, and one had a low grade WHO Grade II astrocytoma. Two dynamic brain PET scans were conducted on each patient, one before and one after treatment with a single oral dose of Jardiance,

SUBMITTER: Ghezzi C 

PROVIDER: S-EPMC11341586 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature