White matter connectivity and social functioning in survivors of pediatric brain tumor.

ABSTRACT:

Objective

Survivors of pediatric brain tumors (SPBT) are at risk for social deficits, fewer friendships, and poor peer relations. SPBT also experience reduced brain connectivity via microstructural disruptions to white matter from neurological insults. Research with other populations implicates white matter connectivity as a key contributor to poor social functioning. This case-controlled diffusion-weighted imaging study evaluated structural connectivity in SPBT and typically developing controls (TDC) and associations between metrics of connectivity and social functioning.

Methods

Diffusion weighted-imaging results from 19 SPBT and 19 TDC were analyzed using probabilistic white matter tractography. Survivors were at least 5 years post-diagnosis and 2 years off treatment. Gra

SUBMITTER: Hocking MC 

PROVIDER: S-EPMC11341593 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature