Proteomic profiling of human dental enamel affected by molar incisor hypomineralisation of different clinical severity grades: an in vitro study.

ABSTRACT:

Purpose

The aim of this study was to explore the potential to profile and distinguish varying clinical severity grades of MIH, compared to normal enamel, using proteomics.

Methods

Liquid chromatography-mass spectrometry analyses were conducted on enamel samples of extracted teeth, from 11 children and adolescents, spanning an age range of 6-18 years. Enamel powder samples were collected from extracted, third molars (n = 3) and first permanent molars diagnosed with MIH (n = 8). The MIH tooth samples were categorized into subgroups based on clinical severity grade. The data were statistically analyzed using ANOVA and Welch's t test.

Results

Teeth affected by MIH exhibited a diverse array of proteins, each with different functions related to dental enamel, distinguishing

SUBMITTER: Rexhaj F 

PROVIDER: S-EPMC11341683 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature