A novel methylation signature predicts extreme long-term survival in glioblastoma.

ABSTRACT:

Purpose

Glioblastoma (GBM) is the most common malignant primary brain tumor with a dismal prognosis of less than 2 years under maximal therapy. Despite the poor prognosis, small fractions of GBM patients seem to have a markedly longer survival than the vast majority of patients. Recently discovered intertumoral heterogeneity is thought to be responsible for this peculiarity, although the exact underlying mechanisms remain largely unknown. Here, we investigated the epigenetic contribution to survival.

Methods

GBM treatment-naïve samples from 53 patients, consisting of 12 extremely long-term survivors (eLTS) patients and 41 median-term survivors (MTS) patients, were collected for DNA methylation analysis. 865 859 CpG sites were examined and processed for detection of different

SUBMITTER: Decraene B 

PROVIDER: S-EPMC11341684 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature