The death of a neurotrauma trial lessons learned from the prematurely halted randomized evaluation of surgery in elderly with traumatic acute subdural hematoma (RESET-ASDH) trial.

ABSTRACT:

Introduction

Acute subdural hematoma (ASDH) due to traumatic brain injury (TBI) constitutes an increasing global health problem, especially in the elderly population. Treatment decisions on surgical versus conservative management pose a neurosurgical dilemma. Large practice variation exists between countries, hospitals, and individual neurosurgeons, illustrating the presence of 'clinical equipoise'. The RESET-ASDH trial aimed to address this dilemma but was terminated prematurely due to insufficient patient recruitment.

Research question

What factors may have contributed to the premature discontinuation of the RESET-ASDH trial?

Materials and methods

The RESET-ASDH was a multicenter randomized controlled trial (RCT) comparing functional outcome at 1 year after early su

SUBMITTER: Singh RD 

PROVIDER: S-EPMC11342112 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature