Modular synthesis of α-branched secondary alkylamines via visible-light-mediated carbonyl alkylative amination.

ABSTRACT: The development of methods for the assembly of secondary α-alkyl amines remains a central challenge to chemical synthesis because of their critical importance in modulating the physical properties of biologically active molecules. Despite decades of intensive research, chemists still rely on selective N-alkylation and carbonyl reductive amination to make most amine products. Here we report the further evolution of a carbonyl alkylative amination process that, for the first time, brings together primary amines, aldehydes and alkyl iodides in a visible-light-mediated multicomponent coupling reaction for the synthesis of a wide range of α-branched secondary alkylamines. In addition to exploring the tolerance and limitations in each reaction component, we also report preliminary applications t

SUBMITTER: Smith MA 

PROVIDER: S-EPMC11342158 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature