Analysis of polyfunctionality for enhanced BAFF-R CAR T-cell therapy for hematologic malignancies.

ABSTRACT:

Abstract

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising immunotherapeutic strategy for eradicating human cancers. Their therapeutic success and durability of clinical responses hinges, in large part, on their functional capacity, including the ability of these engineered cells to simultaneously expand and persist after infusion into patients. CD19 CAR T-cell polyfunctionality, assessing the simultaneous functions of cytokine production, proliferation, and cytotoxicity has been reported to correlate with clinical outcomes. Assay optimization is potentially limited by the heterogeneous nature of CAR T-cell infusion products and target specificity. We optimized a single-cell platform for polyfunctionality using CAR T-cell products manufactured from healthy d

SUBMITTER: Dong Z 

PROVIDER: S-EPMC11342179 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature