Ontology highlight
ABSTRACT:
SUBMITTER: Mugnaini M
PROVIDER: S-EPMC11342238 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Mugnaini Matías M Trinchero Mariela F MF Schinder Alejandro F AF Piatti Verónica C VC Kropff Emilio E
Cell reports 20230906 9
Mammalian hippocampal circuits undergo extensive remodeling through adult neurogenesis. While this process has been widely studied, the specific contribution of adult-born granule cells (aGCs) to spatial operations in the hippocampus remains unknown. Here, we show that optogenetic activation of 4-week-old (young) aGCs in free-foraging mice produces a non-reversible reconfiguration of spatial maps in proximal CA3 while rarely evoking neural activity. Stimulation of the same neuronal cohort on sub ...[more]