Soma-germline communication drives sex maintenance in the Drosophila testis.

ABSTRACT: In adult gonads, disruption of somatic sexual identity leads to defective gametogenesis and infertility. However, the underlying mechanisms by which somatic signals regulate germline cells to achieve proper gametogenesis remain unclear. In our previous study, we introduced the chinmo^{Sex Transformation} (chinmo^ST ) mutant Drosophila testis phenotype as a valuable model for investigating the mechanisms underlying sex maintenance. In chinmo^ST testes, depletion of the Janus Kinase-Signal Transducer and Activator of Transcription downstream effector Chinmo from somatic cyst stem cells (CySCs) feminizes somatic cyst cells and arrests germline differentiation. Here, we use single-cell RNA sequencing to uncover chinmo^ST

SUBMITTER: Zhang R 

PROVIDER: S-EPMC11342250 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature