Associations between accelerometer-derived sedentary behavior and physical activity with white matter hyperintensities in middle-aged to older adults.

ABSTRACT:

Introduction

We examined the relationship between sedentary behavior (SB), moderate-to-vigorous physical activity (MVPA), and white matter hyperintensity (WMH) volumes, a common magnetic resonance imaging (MRI) marker associated with risk of neurodegenerative disease in middle-aged to older adults.

Methods

We used data from the UK Biobank (n = 14,415; 45 to 81 years) that included accelerometer-derived measures of SB and MVPA, and WMH volumes from MRI.

Results

Both MVPA and SB were associated with WMH volumes (β_MVPA = -0.03 [-0.04, -0.01], p < 0.001; β_SB = 0.02 [0.01, 0.03], p = 0.007). There was a significant interaction between SB and MVPA on WMH volumes (β_SB×MVPA = -0.015 [-0.028, -0.001], p _SB×MVPA<

SUBMITTER: Raichlen DA 

PROVIDER: S-EPMC11342350 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature