Graphene Oxide Nanosheets Toxicity in Mice Is Dependent on Protein Corona Composition and Host Immunity.

ABSTRACT: Two-dimension graphene oxide (GO) nanosheets with high and low serum protein binding profiles (high/low hard-bound protein corona/HC_high/low) are used in this study as model materials and screening tools to investigate the underlying roles of the protein corona on nanomaterial toxicities in vivo. We proposed that the in vivo biocompatibility/nanotoxicity of GO is protein corona-dependent and host immunity-dependent. The hypothesis was tested by injecting HC_high/low GO nanosheets in immunocompetent ICR/CD1 and immunodeficient NOD-scid II2rγ^null mice and performed histopathological and hematological evaluation studies on days 1 and 14 post-injection. HC_low GO induced more severe acute lung injury compared to HC_high<

SUBMITTER: Li YT 

PROVIDER: S-EPMC11342366 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature