Gut microbiota mediates ambient PM_2.5 exposure-induced abnormal glucose metabolism via short-chain fatty acids.

ABSTRACT: PM_2.5 exposure has been found to cause gut dysbiosis and impair glucose homeostasis in human and animals, yet their underlying biological connection remain unclear. In the present study, we aim to investigate the biological significance of gut microbiota in PM_2.5-induced glucose metabolic abnormalities. Our results showed that microbiota depletion by antibiotics treatment significantly alleviated PM_2.5-induced glucose intolerance and insulin resistance, as indicated by the intraperitoneal glucose tolerance test, glucose-induced insulin secretion, insulin tolerance test, insulin-induced phosphorylation levels of Akt and GSK-3β in insulin sensitive tissues. In addition, faecal microbiota transplantation (FMT) from PM_2.5-exposed donor mice successfu

SUBMITTER: Shao W 

PROVIDER: S-EPMC11342392 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature