In silico evaluation of the role of Fab glycosylation in cetuximab antibody dynamics.

ABSTRACT:

Introduction

N-glycosylation is a post-translational modification that is highly important for the development of monoclonal antibodies (mAbs), as it regulates their biological activity, particularly in terms of immune effector functions. While typically added at the Fc level, approximately 15-25% of circulating antibodies exhibit glycosylation in the Fab domains as well. To the best of our knowledge, cetuximab (Erbitux^®) is the only therapeutic antibody presenting Fab glycosylation approved world-wide targeting the epidermal growth factor receptor for the treatment of metastatic-colorectal and head and neck cancers. Additionally, it can trigger antibody-dependent cell cytotoxicity (ADCC), a response that typically is influenced by N-glycosylation at Fc level. However, t

SUBMITTER: Saporiti S 

PROVIDER: S-EPMC11342397 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature