Gender differences in major depressive disorder at different ages: a REST-meta-MDD project-based study.

ABSTRACT:

Background

Major depressive disorder (MDD) is a highly heterogeneous disease, with differences in clinical manifestations among depression patients based on onset ages and genders. The neural mechanisms underlying these differences remain unclear. In this study, we utilized resting state functional imaging data from a large sample database and adopted the ReHo method to investigate gender differences in local brain function in MDD patients across different onset age groups.

Methods

The study included 364 MDD patients and 695 healthy participants who were part of the REST-meta-MDD project. Regional homogeneity (ReHo) assessed gender disparities in MDD and healthy individuals within groups delineated by gender and onset age (young group: 18-29 years; middle-aged group: 30-45 y

SUBMITTER: Tian X 

PROVIDER: S-EPMC11342488 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature