Increased of IL-18 levels are associated with periodontitis: a systematic review and meta-analysis.

ABSTRACT:

Background

The presence of a polymicrobial dysbiotic film in direct and constant contact with periodontal tissues initiates the host immune response. Interleukin 18 (IL-18) triggers up-regulates the production of other proinflammatory cytokines (TNF-α, IL-1β, IL-6), creating a vicious cycle that expands the inflammatory and destructive process in the periodontal tissue. A systematic review and meta-analysis was carried out with the main propose to investigate IL-18 expression in different biological samples from subjects with chronic periodontitis.

Methods

The protocol followed PRISMA guidelines and was registered in Open Science Framework (OSF): https://doi.org/10.17605/OSF.IO/BS9GM . A digital search was conducted in the databases PubMed, ScienceDirect, Google Scholar, Web

SUBMITTER: Alarcon-Sanchez MA 

PROVIDER: S-EPMC11342503 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature