Longitudinal associations of plasma amino acid levels with recovery from malarial coma.

ABSTRACT:

Background

Disordered amino acid metabolism is observed in cerebral malaria (CM). This study sought to determine whether abnormal amino acid concentrations were associated with level of consciousness in children recovering from coma. Twenty-one amino acids and coma scores were quantified longitudinally and the data were analysed for associations.

Methods

In a prospective observational study, 42 children with CM were enrolled. Amino acid levels were measured at entry and at frequent intervals thereafter and consciousness was assessed by Blantyre Coma Scores (BCS). Thirty-six healthy children served as controls for in-country normal amino acid ranges. Logistic regression was employed using a generalized linear mixed-effects model to assess associations between out-of-range ami

SUBMITTER: Granger DL 

PROVIDER: S-EPMC11342642 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature