SexAnnoDB, a knowledgebase of sex-specific regulations from multi-omics data of human cancers.

ABSTRACT:

Background

Sexual differences across molecular levels profoundly impact cancer biology and outcomes. Patient gender significantly influences drug responses, with divergent reactions between men and women to the same drugs. Despite databases on sex differences in human tissues, understanding regulations of sex disparities in cancer is limited. These resources lack detailed mechanistic studies on sex-biased molecules.

Methods

In this study, we conducted a comprehensive examination of molecular distinctions and regulatory networks across 27 cancer types, delving into sex-biased effects. Our analyses encompassed sex-biased competitive endogenous RNA networks, regulatory networks involving sex-biased RNA binding protein-exon skipping events, sex-biased transcription factor-gene r

SUBMITTER: Yang M 

PROVIDER: S-EPMC11342657 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature