Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard Aging Brain Study.

ABSTRACT: In addition to amyloid and tau pathology, elevated systemic vascular risk, white matter injury, and reduced cerebral blood flow contribute to late-life cognitive decline. Given the strong collinearity among these parameters, we proposed a framework to extract the independent latent features underlying cognitive decline using the Harvard Aging Brain Study (N = 166 cognitively unimpaired older adults at baseline). We used the following measures from the baseline visit: cortical amyloid, inferior temporal cortex tau, relative cerebral blood flow, white matter hyperintensities, peak width of skeletonized mean diffusivity, and Framingham Heart Study cardiovascular disease risk. We used exploratory factor analysis to extract orthogonal factors from these variables and their interactions. These f

SUBMITTER: Shirzadi Z 

PROVIDER: S-EPMC11342726 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature