Comparative profiling of whole-cell and exosome samples reveals protein signatures that stratify breast cancer subtypes.

ABSTRACT: Identifying novel breast cancer biomarkers will improve patient stratification, enhance therapeutic outcomes, and help develop non-invasive diagnostics. We compared the proteomic profiles of whole-cell and exosomal samples of representative breast cancer cell subtypes to evaluate the potential of extracellular vesicles as non-invasive disease biomarkers in liquid biopsies. Overall, differentially-expressed proteins in whole-cell and exosome samples (which included markers for invasion, metastasis, angiogenesis, and drug resistance) effectively discriminated subtypes; furthermore, our results confirmed that the proteomic profile of exosomes reflects breast cancer cell-of-origin, which underscores their potential as disease biomarkers. Our study will contribute to identifying biomarkers that

SUBMITTER: Andreu Z 

PROVIDER: S-EPMC11342910 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature