Ontology highlight
ABSTRACT:
SUBMITTER: Xie Z
PROVIDER: S-EPMC11342913 | biostudies-literature | 2024 Aug
REPOSITORIES: biostudies-literature
Xie Zhenyu Z Niu Liaoran L Du Kunli K Chen Ling L Zheng Gaozan G Dai Songchen S Dan Hanjun H Duan Lili L Dou Xinyu X Feng Fan F Zhang Jian J Zheng Jianyong J
Cellular and molecular life sciences : CMLS 20240822 1
This study aims to uncover the heterogeneity of endothelial cells (ECs) in colorectal cancer (CRC) and their crucial role in angiogenesis, with a special focus on tip cells. Using single-cell RNA sequencing to profile ECs, our data suggests that CRC ECs predominantly exhibit enhanced angiogenesis and decreased antigen presentation, a shift in phenotype largely steered by tip cells. We also observed that an increase in the density and proportion of tip cells correlates with CRC occurrence, progre ...[more]