Male and female mice respectively form stronger social aversive memories with same and different sex conspecifics.

ABSTRACT: Mice offer a wealth of opportunities for investigating brain circuits regulating multiple behaviors, largely due to their genetic tractability. Social behaviors are of translational relevance, considering both mice and humans are highly social mammals, and disruptions in human social behavior are key symptoms of myriad neuropsychiatric disorders. Stresses related to social experiences are particularly influential in the severity and maintenance of neuropsychiatric disorders like anxiety disorders, and trauma and stressor-related disorders. Yet, induction and study of social stress in mice is disproportionately focused on males, influenced heavily by their natural territorial nature. Conspecific-elicited stress (i.e., defeat), while ethologically relevant, is quite variable and predominantl

SUBMITTER: Beaver JN 

PROVIDER: S-EPMC11343151 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature