Population dynamics in spatial suppression gene drive models and the effect of resistance, density dependence, and life history.

ABSTRACT: Due to their super-Mendelian inheritance, gene drive systems have the potential to provide revolutionary solutions to critical public health and environmental problems. For suppression drives, however, spatial structure can cause "chasing" population dynamics that may postpone target population elimination or even cause the drive to fail. In chasing, wild-type individuals elude the drive and recolonize previously suppressed areas. The drive can re-enter these recolonized areas, but often is not able to catch up to wild-type and finally eliminate it. Previous methods for chasing detection are only suitable to limited parameter ranges. In this study with expanded parameter ranges, we found that the shift from chasing dynamics to static equilibrium outcomes is continuous as drive performance

SUBMITTER: Zhang X 

PROVIDER: S-EPMC11343152 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature