Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis.

ABSTRACT: Influenza-associated pulmonary aspergillosis (IAPA) is a severe complication of influenza infection that occurs in critically ill patients and results in higher mortality compared to influenza infection alone. Interleukin-17 (IL-17) and the Type 17 immune signaling pathway cytokine family are recognized for their pivotal role in fostering protective immunity against various pathogens. In this study, we investigate the role of IL-17 and Type 17 immune signaling components during IAPA. Wild-type mice were challenged with influenza A H1N1 (Flu) and then exposed to Aspergillus fumigatus ATCC42202 resting conidia on day 6 post-influenza infection, followed by the quantification of cytokines and chemokines at 48 hours post-fungal infection. Gene and protein expression levels revealed that

SUBMITTER: Ahmad A 

PROVIDER: S-EPMC11343153 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature