Modeling collagen fibril degradation as a function of matrix microarchitecture.

ABSTRACT: Collagenolytic degradation is a process fundamental to tissue remodeling. The microarchitecture of collagen fibril networks changes during development, aging, and disease. Such changes to microarchitecture are often accompanied by changes in matrix degradability. In vitro, collagen matrices of the same concentration but different microarchitectures also vary in degradation rate. How do different microarchitectures affect matrix degradation? To answer this question, we developed a computational model of collagen degradation. We first developed a lattice model that describes collagen degradation at the scale of a single fibril. We then extended this model to investigate the role of microarchitecture using Brownian dynamics simulation of enzymes in a multi-fibril three dimensional matr

SUBMITTER: Debnath B 

PROVIDER: S-EPMC11343160 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature